Hollis D. Showalter: search on Z-Library

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1

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema

Liu, Xuwen, Wilson, Michael W., Liu, Kun, Lee, Pil, Yeomans, Larisa, Hagen, Susan E., Lin, Cheng-Mao, Wen, Bo, Sun, Duxin, White, Andrew D., Showalter, Hollis D., Antonetti, David A.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 1.49 MB

2020

2

Tyrosine Kinase Inhibitors. 14. Structure−Activity Relationships for Methyl- amino-Substituted Derivatives of 4-[(3-Bromophenyl)amino]-6-(methylamino)- pyrido[3,4- d ]pyrimidine (PD 158780), a Potent and Specific Inhibitor of the Tyrosine Kinase Activity of Receptors for the EGF Family of Growth Factors

Rewcastle, Gordon W., Murray, Donna K., Elliott, William L., Fry, David W., Howard, Curtis T., Nelson, James M., Roberts, Billy J., Vincent, Patrick W., Hollis Showalter, H. D., Winters, R. Thomas, De

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 135 KB

english, 1998

3

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G, Sorenson, Roderick J, Showalter, Hollis D, Murai, Marcelo J, Belcher, Amalia M, Hartley, Thomas, Hess, Jay L, Cierpicki,

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 2.41 MB

english, 2012

4

New generation tamoxifen analogs as potential treatments for amphetamine abuse

Carpenter, Colleen A., Altshuler, Rachel, Zestos, Alexander, Sorenson, Roderick, Jutkiewicz, Emily M., Kennedy, Robert, Showalter, Hollis, Gnegy, Margaret

Journal:

Drug and Alcohol Dependence

Year:

2017

Language:

english

File:

PDF, 54 KB

english, 2017

5

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Hamby, James M., Connolly, Cleo J. C., Schroeder, Mel C., Winters, R. Thomas, Showalter, H. D. Hollis, Panek, Robert L., Major, Terry C., Olsewski, Bronislawa, Ryan, Michael J., Dahring, Tawny

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 171 KB

english, 1997

6

Synthesis and structure–activity relationships of novel substituted 8-amino, 8-thio, and 1,8-pyrazole congeners of antitubercular rifamycin S and rifampin

Yafei Jin, Sumandeep K. Gill, Paul D. Kirchhoff, Baojie Wan, Scott G. Franzblau, George A. Garcia, H.D. Hollis Showalter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 555 KB

english, 2011

7

Rifamycins – Obstacles and opportunities

Paul A. Aristoff, George A. Garcia, Paul D. Kirchhoff, H.D. Hollis Showalter

Journal:

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

8

Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1 H )-ones as Selective Inhibitors of pp60 c - src

Thompson, Andrew M., Rewcastle, Gordon W., Boushelle, Stacey L., Hartl, Brian G., Kraker, Alan J., Lu, Gina H., Batley, Brian L., Panek, Robert L., Showalter, H. D. Hollis, Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 255 KB

english, 2000

9

Tyrosine Kinase Inhibitors. 13. Structure−Activity Relationships for Soluble 7-Substituted 4-[(3-Bromophenyl)amino]pyrido[4,3- d ]pyrimidines Designed as Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Thompson, Andrew M., Murray, Donna K., Elliott, William L., Fry, David W., Nelson, James A., Hollis Showalter, H. D., Roberts, Bill J., Vincent, Patrick W., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

10

Adenosine deaminase inhibitors. Synthesis and biological evaluation of (.+-.)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d][1,3]diazepin-8-ol and some selected C-5 homologs of pentostatin

Showalter, H. D. Hollis, Putt, Sterling R., Borondy, Pal E., Shillis, Joan L.

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 806 KB

english, 1983

11

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

Showalter, Hollis D.

Journal:

Year:

2020

File:

PDF, 5.29 MB

2020

12

Synthesis of double carbon-14 labeled CI-9371 and CI-942, potential new anticancer drugs

James L. Hicks, C. C. Huang, H. D. Hollis Showalter

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1987

Language:

english

File:

PDF, 526 KB

english, 1987

13

Synthesis of 7-substituted 3-aryl-1,6-naphthyridin-2-amines and 7-substituted 3-aryl-1,6-naphthyridin-2(1H )-ones via diazotization of 3-aryl-1,6-naphthyridine-2,7-diamines

Thompson, Andrew M., Hollis Showalter, H. D., Denny, William A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

14

Synthesis of 3,4-dihydro-1(2H)-isoquinolinonesxs

H. D. Hollis Showalter, Anthony D. Sercel, Michael A. Stier, William R. Turner

Journal:

Journal of Heterocyclic Chemistry

Year:

2001

Language:

english

File:

PDF, 39 KB

english, 2001

15

Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription

Zeller, Jörg, Turbiak, Anjanette J., Powelson, Ian A., Lee, Surin, Sun, Duxin, Showalter, H.D. Hollis, Fearon, Eric R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

16

CHEMICAL IONIZATION MASS SPECTROMETRY OF SOME REPRESENTATIVE 16-MEMBERED RING MACROLIDE ANTIBIOTICS

MITSCHER, LESTER A., SHOWALTER, H. D. HOLLIS, FOLTZ, RODGER L.

Journal:

The Journal of Antibiotics

Year:

1973

Language:

english

File:

PDF, 251 KB

english, 1973

17

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity

Beyett, Tyler S., Gan, Xinmin, Reilly, Shannon M., Gomez, Andrew V., Chang, Louise, Tesmer, John J.G., Saltiel, Alan R., Showalter, Hollis D.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.55 MB

english, 2018

18

ChemInform Abstract: A Novel Synthesis of N1-(Substituted)-pyrimido [5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones.

Anjanette J. Turbiak, H. D. Hollis Showalter

Journal:

Year:

2009

File:

PDF, 21 KB

2009

19

STUDIES IN THE SYNTHESIS OF HALOGENATED ANTHRAQUINONES. I. A CONVENIENT PREPARATION OF 1,4-DICHLORO-5-HYDROXY-9,10-ANTHRACENEDIONE

Johnson, Judith L., Hollis Showalter, H. D.

Journal:

Organic Preparations and Procedures International

Year:

1984

Language:

english

File:

PDF, 195 KB

english, 1984

20

Total synthesis of (8R)-3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol (pentostatin), the potent inhibitor of adenosine deaminase

Chan, Eunice, Putt, Sterling R., Showalter, H. D. Hollis, Baker, David C.

Journal:

Journal of Organic Chemistry

Year:

1982

Language:

english

File:

PDF, 1.08 MB

english, 1982

21

Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4- d ]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor

Smaill, Jeff B., Showalter, H. D. Hollis, Zhou, Hairong, Bridges, Alexander J., McNamara, Dennis J., Fry, David W., Nelson, James M., Sherwood, Veronika, Vincent, Patrick W., Roberts, Bill J., Elliott

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

22

Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias

Showalter, H. D. Hollis, Angelo, Mario M., Berman, Ellen M., Kanter, Gerald D., Ortwine, Daniel F., Ross-Kesten, Suzanne G., Sercel, Anthony D., Turner, William R., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.54 MB

english, 1988

23

A SYNTHESIS OF THE PYRANO[3,2- b ]PYRIDINE RING SYSTEM UNDER MILD CONDITIONS

Harikrishnan, Lalgudi S., Boehm, Terri L., Hollis Showalter, H. D.

Journal:

Synthetic Communications

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

24

Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR

McDonald, Alex J., Leon, Deborah R., Markham, Kathleen A., Wu, Bei, Heckendorf, Christian F., Schilling, Kevin, Showalter, Hollis D., Andrews, Philip C., McComb, Mark E., Pushie, M. Jake, Costello, Ca

Journal:

Year:

2019

Language:

english

File:

PDF, 4.45 MB

english, 2019

25

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Smaill, Jeff B., Rewcastle, Gordon W., Loo, Joseph A., Greis, Kenneth D., Chan, O. Helen, Reyner, Eric L., Lipka, Elke, Showalter, H. D. Hollis, Vincent, Patrick W., Elliott, William L., Denny, Willia

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

26

Design, synthesis, and biological activity of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors

Jin, Yafei, Huang, Xiaoqin, Papke, Roger L., Jutkiewicz, Emily M., Showalter, Hollis D., Zhan, Chang-Guo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 822 KB

english, 2017

27

Stereoselective Synthesis of ( S )-3-(Methylamino)-3-(( R )-pyrrolidin-3-yl)propanenitrile

Lall, Manjinder S., Hoge, Garrett, Tran, Tuan P., Kissel, William, Murphy, Sean T., Taylor, Clarke, Hutchings, Kim, Samas, Brian, Ellsworth, Edmund L., Curran, Timothy, Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 445 KB

english, 2012

28

Anticancer anthrapyrazoles. The synthesis of 2-substituted 5-nitro and 5-aminoanthra[1,9-cd]pyrazol-6(2H)-ones

H. D. Hollis Showalter, William R. Turner

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 306 KB

1993

29

Tyrosine Kinase Inhibitors. 16. 6,5,6-Tricyclic Benzothieno[3,2- d ]pyrimidines and Pyrimido[5,4- b ]- and -[4,5- b ]indoles as Potent Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase

Showalter, H. D. Hollis, Bridges, Alexander J., Zhou, Hairong, Sercel, Anthony D., McMichael, Amy, Fry, David W.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 315 KB

english, 1999

30

Fragmentation process occurring in proton-transfer chemical-ionization mass spectrometry

Foltz, Rodger L., Fentiman, Allison F., Mitscher, Lester A., Showalter, H. D. Hollis

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1973

Language:

english

File:

PDF, 232 KB

english, 1973

31

Chemical-ionization mass spectrometry of .BETA.-lactam antibiotics.

MITSCHER, LESTER A., SHOWALTER, H. D. HOLLIS, SHIRAHATA, KUNIKATSU

Journal:

The Journal of Antibiotics

Year:

1975

Language:

english

File:

PDF, 3.38 MB

english, 1975

32

Total syntheses of eburnamonine, quebrachamine, vincadine and epivincadine

Ernest Wenkert, Timothy D.J. Halls, Lawrence D. Kwart, Göran Magnusson, H.D.Hollis Showalter

Journal:

Year:

1981

Language:

english

File:

PDF, 892 KB

english, 1981

33

Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N- and 3-Substituted 2,2'-Dithiobis(1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor Protein Tyrosine Kinases

Palmer, Brian D., Rewcastle, Gordon W., Thompson, Andrew M., Boyd, Maruta, Showalter, H. D. Hollis, Sercel, Anthony D., Fry, David W., Kraker, Alan J., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.14 MB

english, 1995

34

Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners

Showalter, H. D. Hollis

Journal:

Journal of Natural Products

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

35

Development of a Novel Silyl Ether Linker for Solid-Phase Organic Synthesis 1

Boehm, Terri L., Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 92 KB

english, 1996

36

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2- d ]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions.

Smaill, Jeff B., Rewcastle, Gordon W., Bridges, Alexander J., Zhou, Hairong, Showalter, H. D. Hollis, Fry, David W., Nelson, James M., Sherwood, Veronika, Elliott, William L., Vincent, Patrick W., DeJ

Journal:

Journal of Medicinal Chemistry

Year:

2000

File:

PDF, 7 KB

2000

37

Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes

Xu, Hao, Majmudar, Jaimeen D., Davda, Dahvid, Ghanakota, Phani, Kim, Ki H., Carlson, Heather A., Showalter, Hollis D., Martin, Brent R., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 4.04 MB

english, 2015

38

Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Tuan P. Tran, Edmund L. Ellsworth, Michael A. Stier, John M. Domagala, H.D. Hollis Showalter, Stephen J. Gracheck, Martin A. Shapiro, Themis E. Joannides, Rajeshwar Singh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

39

Functionalization of substituted 2-(1H)pyridones. II. Synthetic pathways to c-6 modified 3-cyano- and 3-carboxy-2-(1H)pyridones from a common precursor

H. D. Hollis Showalter, John M. Domagala, Joseph P. Sanchez

Journal:

Journal of Heterocyclic Chemistry

Year:

1981

Language:

english

File:

PDF, 391 KB

english, 1981

40

Synthesis of 6-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones via directed lithiation of 2-substituted 5-aminopyridine derivatives

Rewcastle, Gordon W., Denny, William A., Winters, R. Thomas, Colbry, Norman L., Showalter, H. D. Hollis

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1996

Language:

english

File:

PDF, 872 KB

english, 1996

41

Trimethylsilyl polyphosphate for intramolecular Friedel-Crafts cyclizations

Berman, Ellen M., Showalter, H. D. Hollis

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 320 KB

english, 1989

42

Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3- d ]pyrimidine Inhibitors ‖

Trumpp-Kallmeyer, Susanne, Rubin, J. Ronald, Humblet, Christine, Hamby, James M., Hollis Showalter, H. D.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 266 KB

english, 1998

43

Inhibitors of Adenosine Deaminase: Synthesis of Coformycin and 3′-Deoxycoformycin

Hawkins, L. D., Hanvey, J. C., Boyd, F. L., Baker, David C., Showalter, H. D. Hollis

Journal:

Nucleosides and Nucleotides

Year:

1983

Language:

english

File:

PDF, 647 KB

english, 1983

44

ChemInform Abstract: Design and Synthesis of 2-Nitroimidazoles with Variable Alkylating and Acylating Functionality.

Winters, Thomas, Sercel, Anthony, Suto, Carla, Elliott, William, Leopold, Wilbur, Leopold, Judith, Showalter, Hollis

Journal:

Year:

2014

File:

PDF, 26 KB

2014

45

Ready access to 7,8-dihydro- and 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-ones from simple pyridine precursors

H. D. Hollis Showalter

Journal:

Journal of Heterocyclic Chemistry

Year:

2006

Language:

english

File:

PDF, 392 KB

english, 2006

46

Preparation of N,N′-bis(aryl)guanidines from electron deficient amines via masked carbodiimides

Mark R. Barvian, H.D. Hollis Showalter, Annette M. Doherty

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 202 KB

english, 1997

47

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 219 KB

english, 1998

48

Design, synthesis, and characterization of brequinar conjugates as probes to study DHODH inhibition

Madak, Joseph T, Cuthbertson, Christine R, Chen, Wenmin, Showalter, Hollis D, Neamati, Nouri

Journal:

Chemistry - A European Journal

Year:

2017

Language:

english

File:

PDF, 2.42 MB

english, 2017

49

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

Chris R. Evelyn, Jessica L. Bell, Jenny G. Ryu, Susan M. Wade, Andrew Kocab, Nicole L. Harzdorf, H.D. Hollis Showalter, Richard R. Neubig, Scott D. Larsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.36 MB

english, 2010

50

Quaternary Diamines as Mass Spectrometry Cleavable Crosslinkers for Protein Interactions

Billy Clifford-Nunn, H. D. Hollis Showalter, Philip C. Andrews

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2012

Language:

english

File:

PDF, 736 KB

english, 2012

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